Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779319 | 0.90 | AURKA (0.41) | RAB9ANPC1CSF1RSMN1; SMN2PIM1 | |
| SCHEMBL15362121 | 0.89 | RAB9A (0.35) | RAB9ANPC1CSF1RSMN1; SMN2PIM1 | |
| SCHEMBL1779553 | 0.87 | AURKA (0.44) | CSF1RFLT3PLK4DAPK3MAP4K4 | |
| SCHEMBL1778942 | 0.87 | RXFP1 (0.38) | RAB9ANPC1SMN1; SMN2PIM1PIM3 | |
| SCHEMBL1778788 | 0.86 | FGFR4 (0.36) | RAB9ANPC1SMN1; SMN2PIM1PIM3 | |
| SCHEMBL1778845 | 0.86 | PPARG (0.37) | SMN1; SMN2PIM1PIM3PPARGNR1H4 | |
| SCHEMBL1780074 | 0.85 | SMN1; SMN2 (0.43) | RAB9ANPC1SMN1; SMN2TP53CYP1A2 | |
| SCHEMBL1779132 | 0.84 | NR1H4 (0.37) | PIM1PIM3NPSR1PPARGNR1H4 | |
| SCHEMBL3866037 | 0.84 | RAB9A (0.43) | RAB9ANPC1CSF1RSMN1; SMN2PIM1 | |
| SCHEMBL1778129 | 0.82 | AURKA (0.43) | RAB9ANPC1SMN1; SMN2TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | claimed |