Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 9/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 5/20 | 0.37 |
| ▸ | TAF1 | P21675 | 1/20 | 0.37 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 5/20 | 0.34 |
| ▸ | VRK1 | Q99986 | 2/20 | 0.34 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17780299 | 0.93 | TBK1 (0.38) | TBK1JAK2BRD4LRRK2PLK1 | |
| SCHEMBL17780466 | 0.93 | VRK1 (0.36) | TBK1JAK2BRD4LRRK2PLK1 | |
| SCHEMBL17780483 | 0.91 | TBK1 (0.39) | TBK1JAK2BRD4TAF1PLK1 | |
| SCHEMBL17780429 | 0.89 | TBK1 (0.37) | TBK1JAK2BRD4TAF1RPS6KA6 | |
| SCHEMBL17780495 | 0.87 | CDK9 (0.39) | TBK1JAK2BRD4TAF1LRRK2 | |
| SCHEMBL17780468 | 0.87 | BRD4 (0.39) | JAK2BRD4TAF1LRRK2PLK1 | |
| SCHEMBL17780536 | 0.85 | VRK1 (0.36) | BRD4TAF1RPS6KA6LRRK2VRK1 | |
| SCHEMBL17780354 | 0.84 | VRK1 (0.50) | JAK2BRD4RPS6KA6VRK1 | |
| SCHEMBL17780449 | 0.84 | BRD4 (0.39) | TBK1JAK2BRD4TAF1LRRK2 | |
| SCHEMBL17780504 | 0.84 | BRD4 (0.38) | TBK1JAK2BRD4TAF1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351974-B2 | Substituted pteridinones for the treatment of cancer | OSI Pharmaceuticals, LLC (US) | 2016-05-31 | — | — | US | claimed |