Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 14/20 | 0.39 |
| ▸ | TAF1 | P21675 | 3/20 | 0.39 |
| ▸ | PLK1 | P53350 | 11/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 10/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | TTK | P33981 | 2/20 | 0.34 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.34 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17780483 | 0.93 | TBK1 (0.39) | BRD4TAF1PLK1BRDTPARP1 | |
| SCHEMBL17780504 | 0.93 | BRD4 (0.38) | BRD4TAF1PLK1BRDTPARP1 | |
| SCHEMBL17780482 | 0.93 | PLK1 (0.39) | BRD4TAF1PLK1BRDTPARP1 | |
| SCHEMBL17780480 | 0.93 | PLK1 (0.39) | BRD4TAF1PLK1BRDTPARP1 | |
| SCHEMBL17780376 | 0.91 | ALK (0.35) | BRD4TAF1PLK1BRDTPARP1 | |
| SCHEMBL17780372 | 0.91 | ALK (0.35) | BRD4TAF1PLK1BRDTPARP1 | |
| SCHEMBL17780424 | 0.87 | BRD4 (0.38) | BRD4TAF1PLK1BRDTPARP1 | |
| SCHEMBL17780427 | 0.87 | BRD4 (0.38) | BRD4TAF1PLK1BRDTPARP1 | |
| SCHEMBL17780456 | 0.86 | PLK1 (0.38) | BRD4TAF1PLK1BRDTPARP1 | |
| SCHEMBL17780532 | 0.86 | BRD4 (0.38) | BRD4TAF1PLK1BRDTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351974-B2 | Substituted pteridinones for the treatment of cancer | OSI Pharmaceuticals, LLC (US) | 2016-05-31 | — | — | US | claimed |