Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 8/20 | 0.41 |
| ▸ | HTR2A | P28223 | 6/20 | 0.38 |
| ▸ | HTR7 | P34969 | 5/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | SORD | Q00796 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1774382 | 0.99 | HRH4 (0.47) | HRH4HTR6HTR2AHTR7HTR1A | |
| SCHEMBL1776031 | 0.81 | KIT (0.38) | HRH4HTR6HTR2ADRD3DRD2 | |
| Hydrochloric Acid SCHEMBL1775763 | 0.80 | KIT (0.37) | HRH4HTR6HTR2ADRD3DRD2 | |
| SCHEMBL1775401 | 0.78 | HRH4 (0.45) | HRH4HTR6HTR2AHTR7HTR1A | |
| Hydrochloric Acid SCHEMBL1774702 | 0.77 | HRH4 (0.44) | HRH4HTR6HTR2AHTR7HTR1A | |
| SCHEMBL1774608 | 0.74 | HTR6 (0.51) | HTR6HTR2AHTR7HTR1AHTR2C | |
| SCHEMBL5015937 | 0.74 | HRH4 (0.46) | HRH4HTR2AHTR1AHTR2CDRD3 | |
| Hydrochloric Acid SCHEMBL1775137 | 0.73 | HTR6 (0.50) | HTR6HTR2AHTR7HTR1AHTR2C | |
| SCHEMBL1775441 | 0.73 | HTR6 (0.45) | HRH4HTR6HTR2AHTR7HTR1A | |
| SCHEMBL1775535 | 0.73 | FLT3 (0.46) | HRH4HTR6HTR2AHTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |