Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 13/20 | 0.73 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786045 | 0.89 | AKR1C3 (0.58) | AKR1C3AKR1C1OPRK1OPRM1OPRD1 | |
| SCHEMBL4239496 | 0.88 | AKR1C3 (0.76) | AKR1C3AKR1C1ESR2 | |
| SCHEMBL17786044 | 0.87 | AKR1C3 (0.62) | AKR1C3AKR1C1OPRK1OPRM1OPRD1 | |
| SCHEMBL1264197 | 0.87 | HDAC6 (0.74) | AKR1C3OPRK1OPRM1OPRD1HDAC6 | |
| SCHEMBL17786051 | 0.87 | AKR1C3 (0.56) | AKR1C3OPRK1OPRM1OPRD1HDAC6 | |
| SCHEMBL14751054 | 0.85 | AKR1C3 (0.65) | AKR1C3ESR2 | |
| SCHEMBL17786043 | 0.84 | AKR1C3 (0.61) | AKR1C3AKR1C1OPRK1 | |
| SCHEMBL3280649 | 0.83 | AKR1C3 (0.76) | AKR1C3AKR1C1ESR2 | |
| SCHEMBL5632587 | 0.82 | AKR1C3 (0.77) | AKR1C3AKR1C1HDAC6ESR2 | |
| SCHEMBL4012085 | 0.82 | AKR1C3 (0.73) | AKR1C3AKR1C1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10829453-B2 | Antagonists of the kappa opioid receptor | UNIVERSITY OF KANSAS (US) | 2020-11-10 | — | — | US | disclosed |
| US-20190300486-A1 | ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2019-10-03 | — | — | US | disclosed |
| US-10118896-B2 | Antagonists of the kappa opioid receptor | UNIVERSITY OF KANSAS (US) | 2018-11-06 | — | — | US | disclosed |
| US-20170260141-A1 | ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2017-09-14 | — | — | US | disclosed |
| WO-2016086149-A1 | ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR | UNIVERSITY OF KANSAS (US) | 2016-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10829453-B2 | Antagonists of the kappa opioid receptor | OPRK1, OPRD1, OPRL1 | AKR1C3 3195/4885AKR1C1 3241/4885OPRK1 1/4885 |
| US-10118896-B2 | Antagonists of the kappa opioid receptor | OPRK1, OPRD1, OPRL1 | AKR1C3 3195/4885AKR1C1 3241/4885OPRK1 1/4885 |
| US-20190300486-A1 | ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR | OPRK1, OPRD1, OPRL1 | AKR1C3 3195/4885AKR1C1 3241/4885OPRK1 1/4885 |
| US-20170260141-A1 | ANTAGONISTS OF THE KAPPA OPIOID RECEPTOR | OPRK1, OPRD1, OPRL1 | AKR1C3 3195/4885AKR1C1 3241/4885OPRK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.