SCHEMBL17786245

SCHEMBL17786245

Cc1cccc(Cn2c(Cl)nc3c2c(=O)n(C)c(=O)n3C)c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.71
CYP1A2 P05177 1/20 0.71
CYP3A4 P08684 1/20 0.71
CYP2C9 P11712 1/20 0.71
CYP2C19 P33261 1/20 0.71
HTT P42858 5/20 0.68
LMNA P02545 6/20 0.67
TSHR P16473 4/20 0.67
ALDH1A1 P00352 11/20 0.66
MAPK1 P28482 3/20 0.66
GAA P10253 2/20 0.66
ATM Q13315 1/20 0.66
GFER P55789 1/20 0.66
KDM4E B2RXH2 2/20 0.64
MEN1 O00255 2/20 0.64
KMT2A Q03164 2/20 0.64
MAPT P10636 2/20 0.64
HSD17B10 Q99714 2/20 0.64
NPSR1 Q6W5P4 2/20 0.64
HPGD P15428 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL555173 0.87 HTT (0.78) SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL16122930 0.87 SMN1; SMN2 (0.69) SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL556399 0.87 SMN1; SMN2 (0.69) SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL16028653 0.87 ALDH1A1 (0.76) SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL556289 0.84 SMN1; SMN2 (0.65) SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL17786270 0.84 LMNA (0.64) SMN1; SMN2HTTLMNATSHRALDH1A1
SCHEMBL556785 0.83 ALDH1A1 (0.75) SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL555749 0.83 SMN1; SMN2 (0.64) SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL16029209 0.82 HTT (0.78) SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL14623976 0.82 LMNA (0.84) SMN1; SMN2HTTLMNATSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016086008-A1 SMALL MOLECULE ALDEHYDE DEHYDROGENASE INHIBITORS AND METHODS OF USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2016-06-02 WO disclosed