Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786853 | 0.82 | F11 (0.40) | SMN1; SMN2KLKB1POLBADORA1MAPT | |
| SCHEMBL370914 | 0.82 | NPBWR1 (0.48) | LMNANPC1NPBWR1KDM4EADORA1 | |
| SCHEMBL17786808 | 0.81 | GRIN1 (0.41) | LMNANPC1KMT2AGAARAB9A | |
| SCHEMBL30739173 | 0.81 | NPC1 (0.42) | LMNANPC1KMT2ASMN1; SMN2NPBWR1 | |
| SCHEMBL30739057 | 0.81 | NPC1 (0.42) | LMNANPC1KMT2ASMN1; SMN2NPBWR1 | |
| SCHEMBL30739420 | 0.79 | NPC1 (0.40) | LMNANPC1KMT2ASMN1; SMN2NPBWR1 | |
| SCHEMBL17786902 | 0.76 | KLKB1 (0.47) | KLKB1 | |
| SCHEMBL30739026 | 0.76 | CACNA1H (0.38) | LMNANPC1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL13126531 | 0.75 | KMT2A (0.36) | LMNANPC1KMT2ATSHRALDH1A1 | |
| SCHEMBL773597 | 0.74 | MAPK14 (0.38) | LMNANPC1KMT2ANPBWR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |