Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 9/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370914 | 0.81 | NPBWR1 (0.48) | NPC1LMNACYP11B1CYP11B2 | |
| SCHEMBL17787181 | 0.81 | LMNA (0.38) | NPC1LMNAMAPTGAARAB9A | |
| SCHEMBL30739057 | 0.81 | NPC1 (0.42) | NPC1LMNAMAPTCYP11B1CYP11B2 | |
| SCHEMBL30739173 | 0.81 | NPC1 (0.42) | NPC1LMNAMAPTGAARAB9A | |
| SCHEMBL30739420 | 0.79 | NPC1 (0.40) | NPC1LMNAMAPTCYP11B1CYP11B2 | |
| SCHEMBL17786838 | 0.78 | KLKB1 (0.47) | — | |
| SCHEMBL17786853 | 0.77 | F11 (0.40) | MAPT | |
| SCHEMBL30739026 | 0.75 | CACNA1H (0.38) | NPC1LMNAMAPTCYP11B1CYP11B2 | |
| SCHEMBL16246985 | 0.73 | NPC1 (0.72) | NPC1LMNAMAPTRAB9AKMT2A | |
| SCHEMBL13126531 | 0.72 | KMT2A (0.36) | NPC1LMNAMAPTGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |