Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.31 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.31 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.31 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9712503 | 0.82 | HDAC1 (0.38) | SMN1; SMN2HTTLMNAALDH1A1L3MBTL1 | |
| SCHEMBL15901970 | 0.80 | CES2 (0.42) | KIF11NOTUMMAPT | |
| SCHEMBL8927424 | 0.74 | CA1 (0.36) | KIF11ALDH1A1L3MBTL1NOTUMCA2 | |
| SCHEMBL3023015 | 0.73 | CES2 (0.42) | SMN1; SMN2HTTLMNANOTUMMAPT | |
| SCHEMBL29244555 | 0.71 | TMPRSS4 (0.35) | SMN1; SMN2HTTLMNAKIF11NOTUM | |
| SCHEMBL16408244 | 0.71 | CES2 (0.45) | ALDH1A1MAPT | |
| SCHEMBL18394005 | 0.71 | CES2 (0.47) | NOTUMMAPT | |
| SCHEMBL476764 | 0.70 | CES2 (0.48) | ALDH1A1MEN1KMT2A | |
| SCHEMBL3894397 | 0.70 | RAPGEF4 (0.36) | SMN1; SMN2KIF11ALDH1A1CA2POLB | |
| SCHEMBL18272234 | 0.70 | HTR2A (0.39) | SMN1; SMN2KIF11ALDH1A1CA2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230286907-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-09-14 | — | — | US | disclosed |
| US-20160152561-A1 | SULFONAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC | 2016-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230286907-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | TRPV1, SCN2A, SCN10A | SMN1; SMN2 349/4885HTT 1309/4885LMNA 2874/4885 |
| US-20160152561-A1 | SULFONAMIDES AS MODULATORS OF SODIUM CHANNELS | TRPV1, SCN1A, SCN5A | SMN1; SMN2 282/4885HTT 1784/4885LMNA 3605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.