Sugi Predict

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SCHEMBL1779178

SCHEMBL1779178

CCOC(=O)n1nc(NC(=O)c2ccccc2NC(=O)C2CCOCC2)c2cc(C(=O)NC(C)(C)c3ccccc3F)sc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ MAPK1 P28482 2/20 0.38
▸ HSD17B10 Q99714 2/20 0.38
▸ KDM4E B2RXH2 2/20 0.38
▸ ALDH1A1 P00352 2/20 0.38
▸ GAA P10253 1/20 0.38
▸ SMN1; SMN2 Q16637 2/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ CREBBP Q92793 1/20 0.37
▸ HDAC3 O15379 1/20 0.36
▸ HDAC1 Q13547 1/20 0.36
▸ HDAC2 Q92769 1/20 0.36
▸ RXFP1 Q9HBX9 2/20 0.35
▸ PIP5K1C O60331 1/20 0.34
▸ PIK3CA P42336 1/20 0.34
▸ LMNA P02545 2/20 0.34
▸ TP53 P04637 2/20 0.34
▸ POLB P06746 2/20 0.34
▸ MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1779092 0.91 RXFP1 (0.39) MEN1KMT2AHDAC3HDAC1HDAC2
SCHEMBL1778668 0.90 PDE7A (0.41) MEN1KMT2AMAPK1HSD17B10KDM4E
SCHEMBL1780872 0.87 KMT2A (0.44) MEN1KMT2AMAPK1HSD17B10KDM4E
SCHEMBL1780238 0.87 PTGER1 (0.39) MEN1KMT2AMAPK1HSD17B10KDM4E
SCHEMBL1778410 0.84 ALDH1A1 (0.40) MEN1KMT2AMAPK1HSD17B10KDM4E
SCHEMBL1777881 0.84 HSD17B10 (0.35) MEN1KMT2AMAPK1HSD17B10KDM4E
SCHEMBL1778745 0.84 HSD17B10 (0.35) MEN1KMT2AMAPK1HSD17B10KDM4E
SCHEMBL1780035 0.83 KMT2A (0.38) MEN1KMT2AMAPK1HSD17B10KDM4E
SCHEMBL1780516 0.83 KDM4E (0.38) MEN1KMT2AMAPK1HSD17B10KDM4E
SCHEMBL1779872 0.82 KDR (0.37) MEN1KMT2AMAPK1HSD17B10KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1904503-B1 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES SRL (IT) 2013-11-06 — — EP disclosed
US-7943654-B2 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-17 — — US disclosed
US-20090149457-A1 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-06-11 — — US disclosed
EP-1904503-A1 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.r.l. (IT) 2008-04-02 — — EP disclosed
WO-2007009898-A1 1H-THIENO[2,3-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2007-01-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090149457-A1 1H-Thieno[2,3-c]Pyrazole Compounds Useful as Kinase Inhibitors CCNH, PDK1, MAP3K5 MEN1 4395/4885KMT2A 2397/4885MAPK1 66/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.