Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SCN1A | P35498 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL620764 | 0.82 | ALDH1A1 (0.42) | IKBKBNPC1RAB9AXDH | |
| SCHEMBL16951877 | 0.81 | CYP1A2 (0.43) | IKBKBCYP1A2CYP2C19ALOX15NPC1 | |
| SCHEMBL11855305 | 0.79 | ADRB2 (0.69) | CYP1A2LMNASCN1ASCN5ACYP2D6 | |
| SCHEMBL16216250 | 0.78 | ALOX15 (0.56) | CYP1A2ALOX15KDM4ECYP2D6MAOA | |
| SCHEMBL16962066 | 0.78 | CYP1A2 (0.41) | IKBKBCYP1A2CYP2C19NPC1RAB9A | |
| SCHEMBL10087458 | 0.78 | NPC1 (0.47) | CYP1A2CYP2C19NPC1RAB9AKDM4E | |
| SCHEMBL16960971 | 0.77 | CYP1A2 (0.43) | IKBKBCYP1A2CYP2C19KDM4ELMNA | |
| SCHEMBL19121724 | 0.77 | HTR1B (0.53) | CYP1A2RAB9AKDM4ESCN4ALMNA | |
| SCHEMBL8047112 | 0.76 | KDM4E (0.61) | CYP1A2CYP2C19ALOX15KDM4ESCN4A | |
| SCHEMBL621031 | 0.76 | NPC1 (0.43) | NPC1RAB9AKDM4ELMNAXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102020617-B | The polymorphs body and preparation method thereof of 2- (3- cyano-4-isobutoxy phenyl) -4- methyl-5-thiazole formic acid | 帝人制药株式会社 | 2019-04-23 | — | — | CN | disclosed |
| CN-103788012-B | A kind of method of preparing Febuxostat | Peking Founder Group Co., Ltd. (CN) | 2016-05-25 | — | — | CN | disclosed |
| WO-2012066561-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF 2-ARYLTHIAZOLE DERIVATIVES | MATRIX LABORATORIES LTD (IN) | 2012-05-24 | — | — | WO | disclosed |
| US-7943309-B2 | Prognosing drug response via presence of allelic variation in human leukocyte antigen; side effect reduction and redirection of therapeutic protocols | PHARMIGENE INC. (TW) | 2011-05-17 | — | — | US | disclosed |
| US-20080145846-A1 | HLA ALLELES ASSOCIATED WITH ADVERSE DRUG REACTIONS AND METHODS FOR DETECTING SUCH | ACADEMIA SINICA (TW) | 2008-06-19 | — | — | US | disclosed |