Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.51 |
| ▸ | PTPRA | P18433 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28444192 | 1.00 | FDPS (0.51) | FDPSPTPRAHRH1SMN1; SMN2CYP1A2 | |
| SCHEMBL8636588 | 0.78 | FDPS (0.56) | FDPSPTPRASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL4618294 | 0.78 | NR3C1 (0.55) | FDPSPTPRASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL6638562 | 0.78 | FDPS (0.54) | FDPSPTPRASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL27639696 | 0.75 | SMN1; SMN2 (0.62) | FDPSSMN1; SMN2CYP1A2CYP2C19KDM4E | |
| SCHEMBL9092131 | 0.75 | CYP1A2 (0.53) | FDPSPTPRASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL10411105 | 0.75 | FDPS (0.51) | FDPSPTPRASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL29694017 | 0.75 | CYP1A2 (0.53) | FDPSPTPRASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL7810653 | 0.75 | FDPS (0.51) | FDPSPTPRASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL294785 | 0.75 | CYP1A2 (0.53) | FDPSPTPRASMN1; SMN2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005762-B2 | Pyridine derivatives | ASTELLAS PHARMA INC. (JP) | 2018-06-26 | — | — | US | disclosed |
| US-20170362209-A1 | PYRIDINE DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2017-12-21 | — | — | US | disclosed |
| EP-3228616-A1 | PYRIDINE DERIVATIVES | Astellas Pharma Inc. (JP) | 2017-10-11 | — | — | EP | disclosed |
| WO-2016088864-A1 | PYRIDINE DERIVATIVE | アステラス製薬株式会社 | 2016-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005762-B2 | Pyridine derivatives | LAP3, PREP, DNPEP | FDPS 2062/4885PTPRA 644/4885HRH1 1168/4885 |
| US-20170362209-A1 | PYRIDINE DERIVATIVES | LAP3, PREP, DNPEP | FDPS 2062/4885PTPRA 644/4885HRH1 1168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.