Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.42 |
| ▸ | CLK2 | P49760 | 6/20 | 0.42 |
| ▸ | CLK3 | P49761 | 5/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801059 | 0.84 | PARP1 (0.39) | CSNK1DTLR9TLR8TLR7CHEK1 | |
| SCHEMBL17801050 | 0.79 | MAP2K4 (0.53) | CSNK1DMAPK8MAPK10AAK1 | |
| SCHEMBL8252333 | 0.78 | CSNK1D (0.54) | CSNK1DTLR9TLR8TLR7 | |
| SCHEMBL17801053 | 0.77 | MAP3K5 (0.55) | CSNK1DDYRK1ACHEK1LRRK2MAPK8 | |
| SCHEMBL17801034 | 0.77 | LRRK2 (0.43) | CSNK1DTLR9TLR8TLR7LRRK2 | |
| SCHEMBL17801086 | 0.76 | PDPK1 (0.47) | DYRK1ACLK2CLK3GAKAAK1 | |
| SCHEMBL5378161 | 0.76 | DYRK1A (0.50) | CSNK1DADORA2AADORA1DYRK1ACLK2 | |
| SCHEMBL5387406 | 0.72 | CSNK1D (0.82) | CSNK1DADORA2AADORA1DYRK1ACLK2 | |
| SCHEMBL4079762 | 0.71 | CSNK1D (0.74) | CSNK1DADORA2AADORA1DYRK1ACLK2 | |
| SCHEMBL17801051 | 0.71 | PARP1 (0.44) | DYRK1ACLK2AURKBMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | claimed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |