Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 5/20 | 0.53 |
| ▸ | TTK | P33981 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CPT1A | P50416 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.41 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.41 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801053 | 0.88 | MAP3K5 (0.55) | MAPK8MAP3K5CSNK1DMAPK10MAPK14 | |
| SCHEMBL17801051 | 0.84 | PARP1 (0.44) | MAP2K4PIM1PARP1MAPK1MAPKAPK3 | |
| SCHEMBL17801086 | 0.83 | PDPK1 (0.47) | AAK1 | |
| SCHEMBL17801091 | 0.80 | CPT1A (0.60) | MAP2K4TTKMAPK8MAP3K5CPT1A | |
| SCHEMBL8252333 | 0.80 | CSNK1D (0.54) | MAP2K4PIM1CSNK1DMAPK14 | |
| SCHEMBL17801016 | 0.79 | CSNK1D (0.50) | MAPK8AAK1CSNK1DMAPK10 | |
| SCHEMBL17801059 | 0.79 | PARP1 (0.39) | MAP2K4MAP3K5PIM1CPT1APARP1 | |
| SCHEMBL17801034 | 0.79 | LRRK2 (0.43) | CSNK1D | |
| SCHEMBL17801054 | 0.77 | CPT1A (0.55) | MAP2K4TTKMAPK8MAP3K5CPT1A | |
| SCHEMBL17801078 | 0.73 | CSNK1D (0.49) | MAP2K4TTKMAPK8MAP3K5MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |