Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8252333 | 0.87 | CSNK1D (0.54) | CSNK1DTLR9TLR8TLR7 | |
| SCHEMBL17801056 | 0.83 | TLR9 (0.50) | LRRK2ITKCSNK1DTLR9TLR8 | |
| SCHEMBL17801050 | 0.79 | MAP2K4 (0.53) | CSNK1D | |
| SCHEMBL17801040 | 0.78 | TLR9 (0.51) | LRRK2ITKSLC6A4TLR9TLR8 | |
| SCHEMBL17801049 | 0.77 | CPT1A (0.52) | — | |
| SCHEMBL17801024 | 0.77 | FASN (0.46) | LRRK2TLR9TLR8TLR7 | |
| SCHEMBL17801016 | 0.77 | CSNK1D (0.50) | LRRK2CSNK1DTLR9TLR8TLR7 | |
| SCHEMBL17801059 | 0.77 | PARP1 (0.39) | LRRK2CSNK1DTLR9TLR8TLR7 | |
| SCHEMBL17801053 | 0.76 | MAP3K5 (0.55) | LRRK2CSNK1D | |
| SCHEMBL17801018 | 0.75 | CSNK1D (0.50) | LRRK2ITKCSNK1DTRPA1SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |