Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801016 | 0.84 | CSNK1D (0.50) | CSNK1DTLR9TLR8TLR7LRRK2 | |
| SCHEMBL17801053 | 0.82 | MAP3K5 (0.55) | CSNK1DMAP3K5LRRK2CHEK1 | |
| SCHEMBL17801057 | 0.80 | CPT1A (0.51) | CPT2CPT1A | |
| SCHEMBL17801050 | 0.79 | MAP2K4 (0.53) | PARP1MAP2K4CSNK1DMAP3K5CPT1A | |
| SCHEMBL8252333 | 0.78 | CSNK1D (0.54) | MAP2K4CSNK1DTLR9TLR8TLR7 | |
| SCHEMBL17801086 | 0.78 | PDPK1 (0.47) | — | |
| SCHEMBL5373489 | 0.78 | MAP2K4 (0.42) | PARP1MAP2K4MAP3K5PRKD1MAP4K4 | |
| SCHEMBL17801034 | 0.77 | LRRK2 (0.43) | CSNK1DTLR9TLR8TLR7LRRK2 | |
| SCHEMBL5801677 | 0.73 | MAP2K4 (0.54) | PARP1MAP2K4MAP3K5PIM1 | |
| SCHEMBL17801051 | 0.71 | PARP1 (0.44) | PARP1MAP2K4PIM1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |