Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.53 |
| ▸ | KHK | P50053 | 4/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 12/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801074 | 0.76 | MAP3K5 (0.55) | MAPK8MAPK10 | |
| SCHEMBL4219269 | 0.69 | KHK (0.56) | HPGDSKHK | |
| SCHEMBL4219336 | 0.69 | HPGDS (0.55) | HPGDSKHK | |
| SCHEMBL17801012 | 0.68 | MAP3K5 (0.54) | MAPK8MAPK10 | |
| SCHEMBL18013554 | 0.68 | NR3C1 (0.55) | HPGDSKHKNR3C1MAPK8MAPK10 | |
| SCHEMBL13623903 | 0.67 | NR3C1 (0.60) | HPGDSKHKNR3C1MAPK8MAPK10 | |
| SCHEMBL4225251 | 0.67 | MAPK13 (0.53) | HPGDS | |
| SCHEMBL4229997 | 0.66 | NR3C1 (0.58) | HPGDSNR3C1MAPK10 | |
| SCHEMBL4220428 | 0.66 | HPGDS (0.51) | HPGDSKHK | |
| SCHEMBL4222804 | 0.66 | HPGDS (0.51) | HPGDSKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |