Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.35 |
| ▸ | FASN | P49327 | 2/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 5/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 2/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801094 | 0.84 | PLK1 (0.35) | PLK1TLR9TLR8TLR7RXRA | |
| SCHEMBL5374854 | 0.80 | KDM1A (0.40) | CMKLR1PRKDCKDM1ARXRARXRB | |
| SCHEMBL17801026 | 0.77 | USP30 (0.37) | CMKLR1RXRARXRBRXRG | |
| SCHEMBL5378280 | 0.76 | RXRA (0.36) | CMKLR1PRKDCKDM1ARXRARXRB | |
| SCHEMBL5373251 | 0.76 | CMKLR1 (0.38) | CMKLR1PRKDCRXRARXRBRXRG | |
| SCHEMBL5374037 | 0.76 | KDM1A (0.37) | CMKLR1PRKDCKDM1ARXRARXRB | |
| SCHEMBL5373390 | 0.76 | CSNK1A1 (0.38) | CMKLR1PRKDCKDM1ARXRARXRB | |
| SCHEMBL5372775 | 0.76 | CMKLR1 (0.39) | CMKLR1PRKDCKDM1ARXRARXRB | |
| SCHEMBL5372768 | 0.76 | CMKLR1 (0.42) | CMKLR1PRKDCKDM1ARXRARXRB | |
| SCHEMBL5379711 | 0.76 | PRKDC (0.40) | CMKLR1PRKDCKDM1AMERTKAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |