Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801034 | 0.78 | LRRK2 (0.43) | TLR9TLR8TLR7LRRK2ITK | |
| SCHEMBL5384307 | 0.73 | CYP2C19 (0.48) | TLR9TLR8TLR7 | |
| SCHEMBL17801032 | 0.72 | TLR8 (0.46) | TLR9TLR8TLR7LRRK2ITK | |
| SCHEMBL2636042 | 0.70 | ALDH1A1 (0.61) | TLR9TLR8TLR7 | |
| SCHEMBL16463738 | 0.70 | CYP2C19 (0.55) | TLR9TLR8TLR7 | |
| SCHEMBL16463737 | 0.70 | CYP2C19 (0.55) | TLR9TLR8TLR7 | |
| SCHEMBL19385363 | 0.69 | USP30 (0.54) | TLR9TLR8TLR7 | |
| SCHEMBL21065192 | 0.69 | HPGD (0.51) | TLR9TLR8TLR7 | |
| SCHEMBL13114282 | 0.69 | ALDH1A1 (0.57) | TLR9TLR8TLR7 | |
| SCHEMBL23115433 | 0.68 | TLR8 (1.00) | TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |