Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801040 | 0.72 | TLR9 (0.51) | TLR8TLR7TLR9LRRK2TRPA1 | |
| SCHEMBL5372872 | 0.71 | LRRK2 (0.61) | LRRK2TRPA1SCN5ASCN9AITK | |
| SCHEMBL17801038 | 0.70 | CMKLR1 (0.35) | TLR8TLR7TLR9 | |
| SCHEMBL5385497 | 0.70 | LRRK2 (0.52) | LRRK2TRPA1SCN5ASCN9AITK | |
| SCHEMBL1664137 | 0.69 | LRRK2 (0.58) | LRRK2TRPA1SCN5ASCN9AITK | |
| SCHEMBL17801064 | 0.69 | DCLK1 (0.65) | LRRK2TRPA1SCN5ASCN9AITK | |
| SCHEMBL5374137 | 0.69 | LRRK2 (0.51) | LRRK2TRPA1SCN5ASCN9AITK | |
| SCHEMBL13049888 | 0.69 | MAP2K4 (0.54) | TLR8TLR7LRRK2ITK | |
| SCHEMBL17801023 | 0.67 | LRRK2 (0.52) | LRRK2TRPA1SCN5ASCN9AITK | |
| SCHEMBL5375172 | 0.67 | MAP2K4 (0.45) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |