Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801066 | 0.89 | HCRTR1 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL17801089 | 0.88 | ALDH1A1 (0.42) | ALDH1A1KMT2AMAPTNPSR1TSHR | |
| SCHEMBL12098306 | 0.78 | KMT2A (0.61) | ALDH1A1KMT2AMAPTNPSR1TSHR | |
| SCHEMBL12098303 | 0.78 | KMT2A (0.61) | ALDH1A1KMT2AMAPTNPSR1TSHR | |
| SCHEMBL19385176 | 0.77 | USP30 (0.56) | ALDH1A1KMT2AMAPTNPSR1TSHR | |
| SCHEMBL17801026 | 0.76 | USP30 (0.37) | HCRTR1HCRTR2 | |
| SCHEMBL15373546 | 0.75 | ALDH1A1 (0.53) | ALDH1A1KMT2AMAPTNPSR1TSHR | |
| SCHEMBL23248002 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KMT2AMAPTNPSR1TSHR | |
| SCHEMBL13298120 | 0.75 | ALDH1A1 (0.57) | ALDH1A1KMT2AMAPTNPSR1TSHR | |
| SCHEMBL22602035 | 0.75 | ALDH1A1 (0.54) | ALDH1A1KMT2AMAPTNPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |