Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1,4-Dichlorobenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | CA1 | P00915 | 8/20 | 0.57 |
| ▸ | CA2 | P00918 | 8/20 | 0.57 |
| ▸ | CA9 | Q16790 | 4/20 | 0.57 |
| ▸ | CA12 | O43570 | 3/20 | 0.57 |
| ▸ | CA3 | P07451 | 3/20 | 0.57 |
| ▸ | CA4 | P22748 | 3/20 | 0.57 |
| ▸ | CA6 | P23280 | 3/20 | 0.57 |
| ▸ | CA5A | P35218 | 3/20 | 0.57 |
| ▸ | CA7 | P43166 | 3/20 | 0.57 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.57 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.57 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,4-Dichlorobenzene SCHEMBL1303192 | 0.93 | ALDH1A1 (0.63) | ALDH1A1CYP3A4MAPK1CA1CA2 | |
| SCHEMBL125763 | 0.85 | ALDH1A1 (0.62) | ALDH1A1CYP3A4MAPK1CA1CA2 | |
| Chlorobenzene SCHEMBL28099603 | 0.85 | TSHR (0.61) | ALDH1A1CYP3A4MAPK1CA1CA2 | |
| SCHEMBL6913638 | 0.81 | ALDH1A1 (0.65) | ALDH1A1CYP3A4MAPK1CA1CA2 | |
| SCHEMBL10953685 | 0.81 | ALDH1A1 (0.56) | ALDH1A1CYP3A4MAPK1CA1CA2 | |
| 4-Chloroaniline SCHEMBL27739703 | 0.81 | MEN1 (0.71) | ALDH1A1CYP3A4MAPK1CA1CA2 | |
| SCHEMBL6908824 | 0.79 | ALDH1A1 (0.62) | ALDH1A1CYP3A4MAPK1CA1CA2 | |
| SCHEMBL6915856 | 0.79 | ALDH1A1 (0.62) | ALDH1A1CYP3A4MAPK1CA1CA2 | |
| SCHEMBL6915327 | 0.79 | ALDH1A1 (0.62) | ALDH1A1CYP3A4MAPK1CA1CA2 | |
| SCHEMBL6917676 | 0.79 | ALDH1A1 (0.62) | ALDH1A1CYP3A4MAPK1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103958585-B | As the ethylene/propene/copolymer-maleic anhydride of impact modifying agent in the FR Merlon of the glass fiber reinforcement for EE field | 科思创德国股份有限公司 | 2016-09-14 | — | — | CN | claimed |
| CN-110267798-B | Method of manufacturing an object by additive manufacturing using a polycarbonate build material having improved flow capability | 科思创德国股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| EP-3582955-B1 | METHOD FOR MANUFACTURING AN OBJECT BY MEANS OF AN ADDITIVE PRODUCTION PROCESS USING A POLYCARBONATE CONSTRUCTION MATERIAL WITH IMPROVED FLOWABILITY | COVESTRO DEUTSCHLAND AG (DE) | 2020-12-23 | — | — | EP | disclosed |
| US-10717871-B2 | Flame-retardant, glass fiber-containing molding compounds containing siloxane-containing polycarbonate block co-condensate | COVESTRO DEUTSCHLAND AG (DE) | 2020-07-21 | — | — | US | disclosed |
| EP-3227386-B1 | POLYCARBONATE COMPOSITIONS CONTAINING POLYETHYLENE WAX | COVESTRO DEUTSCHLAND AG (DE) | 2020-07-15 | — | — | EP | disclosed |
| CN-107207842-B | Polycarbonate compositions containing polyethylene wax | 科思创德国股份有限公司 | 2019-11-05 | — | — | CN | disclosed |
| CN-110267798-A | Using the polycarbonate building material with improved fluid ability by the method for increasing material manufacturing legal system divine force that created the universe body | 科思创德国股份有限公司 | 2019-09-20 | — | — | CN | disclosed |
| US-10189941-B2 | Polycarbonate compositions containing polyethylene wax | COVESTRO DEUTSCHLAND AG (DE) | 2019-01-29 | — | — | US | disclosed |
| WO-2018149831-A1 | METHOD FOR PRODUCING AN OBJECT BY MEANS OF AN ADDITIVE MANUFACTURING PROCESS USING A POLYCARBONATE BUILDING MATERIAL WITH IMPROVED FLOWABILITY | COVESTRO DEUTSCHLAND AG (DE) | 2018-08-23 | — | — | WO | disclosed |
| EP-3227371-B1 | FILLED POLYCARBONATE COMPOSITIONS WITH IMPROVED FLOWABILITY AND HIGH STIFFNESS | COVESTRO DEUTSCHLAND AG (DE) | 2018-07-04 | — | — | EP | disclosed |
| CN-103958585-A | Ethylene-propylene-maleic acid anhydride copolymer as impact modifier in glass-fiber reinforced, flame-retardant polycarbonates for the ee sector | BAYER IP GMBH | 2014-07-30 | — | — | CN | disclosed |
| CN-103874734-A | Polycarbonate comprising glass fibres | BAYER IP GMBH | 2014-06-18 | — | — | CN | disclosed |
| CN-103391970-A | Flame-retardant UV-protected polycarbonate moulding compounds having a low molecular weight | BAYER IP GMBH | 2013-11-13 | — | — | CN | disclosed |
| CN-103189203-A | Flame-protected article having a high level of transmission | BAYER IP GMBH | 2013-07-03 | — | — | CN | disclosed |
| CN-102725341-A | Polycarbonate compositions with improved flame retardancy for extrusion applications | BAYER MATERIALSCIENCE AG | 2012-10-10 | — | — | CN | disclosed |
| CN-101784600-A | Molded parts with improved surface | BAYER MATERIALSCIENCE AG | 2010-07-21 | — | — | CN | disclosed |
| CN-101657498-A | Products with improved flame retardancy | BAYER MATERIALSCIENCE AG DE | 2010-02-24 | — | — | CN | disclosed |
| CN-1503821-A | Flame-retardant polycarbonate moulding compounds having antistatic properties | — | 2004-06-09 | — | — | CN | disclosed |
| CN-1068895-C | Flame-resistant polycarbonate moulding compositions | BAYER AG (DE) | 2001-07-25 | — | — | CN | disclosed |
| CN-1128277-A | Flame-resistant polycarbonate moulding compositions | BAYER AG (DE) | 1996-08-07 | — | — | CN | disclosed |