Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18338552 | 0.73 | GRM2 (0.32) | NPC1 | |
| SCHEMBL29544566 | 0.70 | PIK3C3 (0.37) | ALOX5MAPKAPK2RPS6KA3HRH3PIK3C3 | |
| SCHEMBL34469210 | 0.69 | MAPKAPK2 (0.34) | ALOX5MAPKAPK2RPS6KA3TSHRCDC7 | |
| SCHEMBL24730822 | 0.69 | MAPKAPK2 (0.34) | ALOX5MAPKAPK2RPS6KA3TSHRCDC7 | |
| SCHEMBL24730818 | 0.69 | MAPKAPK2 (0.34) | ALOX5MAPKAPK2RPS6KA3TSHRCDC7 | |
| SCHEMBL24934671 | 0.67 | PIK3C3 (0.42) | ALOX5PIK3C3NPC1RAB9A | |
| SCHEMBL4207853 | 0.67 | CDC7 (0.50) | RPS6KA3CDC7 | |
| SCHEMBL19253533 | 0.66 | GABRG2 (0.31) | — | |
| SCHEMBL30142552 | 0.66 | ALOX5 (0.33) | ALOX5MAPKAPK2TSHRCDC7NPC1 | |
| SCHEMBL15898814 | 0.66 | ALOX5 (0.38) | ALOX5MAPKAPK2RPS6KA3TSHRHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227295-A1 | 6,7-DIHYDROPYRAZOLO[1,5- ]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | Janssen Pharmaceutica NV (BE) | 2017-10-11 | — | — | EP | disclosed |
| WO-2016087487-A1 | 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-09 | — | — | WO | disclosed |