Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24934670 | 0.82 | PTGS1 (0.31) | PIK3C3PTGS2PTGS1 | |
| SCHEMBL29544566 | 0.77 | PIK3C3 (0.37) | PIK3C3ALOX5 | |
| SCHEMBL24860256 | 0.69 | PTGS1 (0.32) | PTGS2PTGS1NPC1RAB9AHDAC3 | |
| SCHEMBL3123945 | 0.69 | CDC7 (0.44) | PTGS2PTGS1ALOX5PLATNR3C2 | |
| SCHEMBL17801738 | 0.67 | ALOX5 (0.35) | PIK3C3ALOX5NPC1RAB9A | |
| SCHEMBL24934385 | 0.67 | KDM4E (0.33) | PTGS2PTGS1 | |
| Iodide SCHEMBL29981811 | 0.66 | KDM4E (0.32) | PTGS2PTGS1 | |
| SCHEMBL21887773 | 0.63 | PTGS2 (0.34) | PTGS2PTGS1PDE4BPDE3AHDAC3 | |
| SCHEMBL31409374 | 0.61 | PLAT (0.34) | PLATGAA | |
| SCHEMBL24730818 | 0.60 | MAPKAPK2 (0.34) | ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115151543-B | Fused tricyclic compounds and medical uses thereof | 日本烟草产业株式会社 | 2024-12-17 | — | — | CN | disclosed |
| US-20230025880-A1 | FUSED TRICYCLIC COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2023-01-26 | — | — | US | disclosed |
| US-20230025880-A1 | FUSED TRICYCLIC COMPOUND AND MEDICINAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2023-01-26 | — | — | US | disclosed |
| CN-115151543-A | Fused tricyclic compounds and medical use thereof | 日本烟草产业株式会社 | 2022-10-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230025880-A1 | FUSED TRICYCLIC COMPOUND AND MEDICINAL USE THEREOF | PC, PCK2, AGK | PIK3C3 1876/4885PTGS2 789/4885PTGS1 597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.