Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | TLR4 | O00206 | 1/20 | 0.49 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25666819 | 0.94 | MAPT (0.64) | MAPTTLR4TLR2ALDH1A1HIF1A | |
| SCHEMBL29739619 | 0.94 | MAPT (0.64) | MAPTTLR4TLR2ALDH1A1HIF1A | |
| SCHEMBL3127806 | 0.88 | ALDH1A1 (0.49) | MAPTALDH1A1HIF1ALMNANPC1 | |
| SCHEMBL12210768 | 0.88 | MAPT (0.60) | MAPTTLR4TLR2ALDH1A1LMNA | |
| SCHEMBL29739504 | 0.87 | MAPT (0.62) | MAPTALDH1A1HIF1ALMNANPC1 | |
| SCHEMBL1189617 | 0.87 | MAPT (0.62) | MAPTALDH1A1HIF1ALMNANPC1 | |
| SCHEMBL14334509 | 0.86 | PTGES (0.49) | MAPTALDH1A1HIF1ALMNANPC1 | |
| SCHEMBL20982525 | 0.85 | CHRNB2 (0.50) | MAPTALDH1A1HIF1AVCAM1 | |
| SCHEMBL14334126 | 0.84 | ALDH1A1 (0.49) | MAPTALDH1A1HIF1ALMNAKMT2A | |
| SCHEMBL15923825 | 0.84 | MAPT (0.56) | MAPTTLR4TLR2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107205993-B | Organic compounds | 细胞内治疗公司 | 2021-03-09 | — | — | CN | disclosed |
| EP-3226862-B1 | PHOSPHODIESTERASE 2 (PDE2) INHIBITORY COMPOUNDS | INTRA CELLULAR THERAPIES INC (US) | 2020-07-08 | — | — | EP | disclosed |
| US-10543194-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190000807-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2019-01-03 | — | — | US | disclosed |
| US-10105349-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2018-10-23 | — | — | US | disclosed |
| US-20170360753-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2017-12-21 | — | — | US | disclosed |
| EP-3226862-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2017-10-11 | — | — | EP | disclosed |
| WO-2016090382-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170360753-A1 | ORGANIC COMPOUNDS | PDE2A, PDE12, PDE3A | MAPT 1514/4885TLR4 4534/4885TLR2 4496/4885 |
| US-10105349-B2 | Organic compounds | PDE2A, PDE12, PDE3A | MAPT 1514/4885TLR4 4534/4885TLR2 4496/4885 |
| US-20190000807-A1 | ORGANIC COMPOUNDS | PDE2A, PDE12, PDE3A | MAPT 1514/4885TLR4 4534/4885TLR2 4496/4885 |
| US-10543194-B2 | Organic compounds | PDE2A, PDE12, PDE3A | MAPT 1514/4885TLR4 4534/4885TLR2 4496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.