Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30860915 | 0.83 | CREBBP (0.47) | CREBBPLMNAHTTALDH1A1CYP3A4 | |
| SCHEMBL27227845 | 0.83 | CREBBP (0.47) | CREBBPLMNAHTTALDH1A1CYP3A4 | |
| SCHEMBL27227902 | 0.81 | CREBBP (0.46) | CREBBPLMNAHTTALDH1A1CYP3A4 | |
| SCHEMBL22411798 | 0.81 | CREBBP (0.43) | CREBBPLMNAHTTALDH1A1CYP3A4 | |
| SCHEMBL31543922 | 0.78 | MAPT (0.41) | CREBBPLMNAHTTALDH1A1CYP3A4 | |
| SCHEMBL22411925 | 0.78 | CREBBP (0.46) | CREBBPLMNAHTTALDH1A1CYP3A4 | |
| SCHEMBL27227910 | 0.78 | CREBBP (0.49) | CREBBPLMNAHTTALDH1A1CYP3A4 | |
| SCHEMBL27227826 | 0.78 | VCAM1 (0.47) | CREBBPLMNAHTTALDH1A1CYP3A4 | |
| SCHEMBL10596779 | 0.77 | HPRT1 (0.46) | CREBBPLMNAHTTALDH1A1CYP3A4 | |
| SCHEMBL15910918 | 0.77 | ERN1 (0.56) | CREBBPLMNAHTTALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594305-A1 | TEAD INHIBITORS AND METHODS OF USES THEREOF | Insilico Medicine IP Limited (HK) | 2025-08-06 | — | — | EP | disclosed |
| CN-119968359-A | TEAD inhibitors and methods of use thereof | 英矽智能科技知识产权有限公司 | 2025-05-09 | — | — | CN | disclosed |
| US-12103915-B2 | TEAD inhibitors and methods of uses thereof | INSILICO MEDICINE IP LIMITED (HK) | 2024-10-01 | — | — | US | disclosed |
| US-20240174647-A1 | KINASE MODULATORS AND METHODS OF USE THEREOF | NEURON23, INC. | 2024-05-30 | — | — | US | disclosed |
| US-20240166608-A1 | TEAD INHIBITORS AND METHODS OF USES THEREOF | INSILICO MEDICINE IP LIMITED (HK) | 2024-05-23 | — | — | US | disclosed |
| WO-2024073073-A2 | KINASE MODULATORS AND METHODS OF USE THEREOF | NEURON23, INC. (US) | 2024-04-04 | — | — | WO | disclosed |
| WO-2024067773-A1 | TEAD INHIBITORS AND METHODS OF USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2024-04-04 | — | — | WO | disclosed |
| US-9145414-B2 | 1,2,4-triazine-6-carboxamide derivative | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-09-29 | — | — | US | disclosed |
| US-20140343038-A1 | 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-11-20 | — | — | US | disclosed |
| EP-2762476-A1 | 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE | Taiho Pharmaceutical Co., Ltd. (JP) | 2014-08-06 | — | — | EP | disclosed |
| US-8765743-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-07-01 | — | — | US | disclosed |
| US-8765743-B2 | Compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-07-01 | — | — | US | disclosed |
| US-20110118246-A1 | Novel Compounds | GLAXO GROUP LIMITED (GB) | 2011-05-19 | — | — | US | disclosed |
| US-20110118246-A1 | Novel Compounds | GLAXO GROUP LIMITED (GB) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12103915-B2 | TEAD inhibitors and methods of uses thereof | TEAD2, TEAD3, TEAD4 | CREBBP 1878/4885LMNA 2460/4885HTT 2577/4885 |
| US-20240166608-A1 | TEAD INHIBITORS AND METHODS OF USES THEREOF | TEAD2, TEAD3, TEAD4 | CREBBP 1878/4885LMNA 2460/4885HTT 2577/4885 |
| US-20140343038-A1 | 1,2,4-TRIAZINE-6-CARBOXAMIDE DERIVATIVE | SYK, BTK, JAK2 | CREBBP 1352/4885LMNA 4412/4885HTT 2896/4885 |
| US-20110118246-A1 | Novel Compounds | PIK3CA, PIK3C2B, PIK3CD | CREBBP 1346/4885LMNA 4734/4885HTT 3190/4885 |
| US-20240174647-A1 | KINASE MODULATORS AND METHODS OF USE THEREOF | LRRK2, MAP3K20, MAP3K5 | CREBBP 994/4885LMNA 2647/4885HTT 466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.