Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1961769 | 0.88 | CHRNB2 (0.57) | CHRNB2CHRNA4ALDH1A1MAPTLMNA | |
| SCHEMBL1965344 | 0.85 | RAB9A (0.53) | CHRNB2CHRNA4ALDH1A1MAPTLMNA | |
| SCHEMBL1963656 | 0.84 | CHRNB2 (0.53) | CHRNB2CHRNA4ALDH1A1MAPTLMNA | |
| SCHEMBL1962192 | 0.83 | CHRNB2 (0.59) | CHRNB2CHRNA4ALDH1A1MAPTLMNA | |
| SCHEMBL30578533 | 0.82 | MAPT (0.61) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A | |
| SCHEMBL8915357 | 0.82 | MAPT (0.61) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A | |
| SCHEMBL14785348 | 0.81 | MCHR1 (0.53) | CHRNB2CHRNA4ALDH1A1MAPTKMT2A | |
| SCHEMBL1962847 | 0.81 | KMT2A (0.49) | CHRNB2CHRNA4ALDH1A1MAPTLMNA | |
| SCHEMBL7569094 | 0.81 | MAPT (0.58) | ALDH1A1MAPTLMNAKMT2AMEN1 | |
| SCHEMBL1962346 | 0.81 | CHRNB2 (0.58) | CHRNB2CHRNA4ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BUB1, BUB1B, TTBK1 | CHRNB2 3727/4885CHRNA4 4753/4885ALDH1A1 2972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.