Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 6/20 | 0.35 |
| ▸ | TCF4 | P15884 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 2/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13281801 | 0.85 | PSEN1 (0.37) | PDK1EZH2PSEN1PSEN2APH1B | |
| SCHEMBL18829965 | 0.85 | PSEN1 (0.37) | PDK1EZH2PSEN1PSEN2APH1B | |
| SCHEMBL15710346 | 0.82 | ALDH1A1 (0.38) | EZH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17804355 | 0.81 | EZH2 (0.41) | EZH2TCF4CTNNB1ALDH1A1HPGD | |
| SCHEMBL18830454 | 0.80 | EZH2 (0.50) | EZH2 | |
| SCHEMBL13279921 | 0.75 | EZH2 (0.39) | EZH2 | |
| SCHEMBL18830476 | 0.73 | CRHR1 (0.38) | EZH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL13279996 | 0.73 | CRHR1 (0.38) | EZH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15710286 | 0.72 | EZH2 (0.42) | EZH2CNR1 | |
| SCHEMBL15710105 | 0.71 | EZH2 (0.72) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | disclosed |
| EP-2697198-B1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2016-06-08 | — | — | EP | disclosed |