Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.42 |
| ▸ | INSR | P06213 | 14/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 14/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 9/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777677 | 0.92 | AURKA (0.52) | AURKAINSRALKABL1BCR | |
| SCHEMBL15362089 | 0.92 | KIT (0.40) | AURKAINSRALKABL1KIT | |
| SCHEMBL1780558 | 0.88 | KDR (0.40) | AURKA | |
| SCHEMBL3868697 | 0.86 | INSR (0.43) | AURKAINSRALKABL1KIT | |
| SCHEMBL1779993 | 0.86 | AURKA (0.45) | AURKAINSRALKABL1BCR | |
| SCHEMBL1779553 | 0.85 | AURKA (0.44) | AURKAINSRALKABL1BCR | |
| SCHEMBL1779963 | 0.85 | IGF1R (0.52) | AURKAINSRALKABL1BCR | |
| SCHEMBL1779339 | 0.84 | INSR (0.45) | AURKAINSRALKABL1BCR | |
| SCHEMBL15362112 | 0.83 | AURKA (0.44) | AURKAINSRALKABL1BCR | |
| SCHEMBL1778772 | 0.82 | INSR (0.47) | AURKAINSRALKABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | claimed |
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |