Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.32 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1778545 | 0.90 | AURKA (0.40) | KDRFGFR1NPC1RAB9AKMT2A | |
| SCHEMBL15362157 | 0.90 | KDR (0.39) | KDRFGFR1NPC1RAB9AKMT2A | |
| SCHEMBL1780489 | 0.88 | AURKA (0.42) | AURKA | |
| SCHEMBL3868186 | 0.85 | KDR (0.42) | KDRFGFR1NPC1RAB9AKMT2A | |
| SCHEMBL1779872 | 0.84 | KDR (0.37) | KDRFGFR1NPC1RAB9AKMT2A | |
| SCHEMBL1778845 | 0.84 | PPARG (0.37) | KDRFGFR1KMT2ASMN1; SMN2PPARG | |
| SCHEMBL1778942 | 0.84 | RXFP1 (0.38) | KDRFGFR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1778788 | 0.83 | FGFR4 (0.36) | KDRFGFR1NPC1RAB9AKMT2A | |
| SCHEMBL1778010 | 0.81 | RAB9A (0.37) | KDRFGFR1NPC1RAB9AKMT2A | |
| SCHEMBL1779132 | 0.81 | NR1H4 (0.37) | KDRFGFR1NPSR1PPARGNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | claimed |
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |