Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.57 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.57 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.57 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.57 |
| ▸ | WDR5 | P61964 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | OTUD7B | Q6GQQ9 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17806355 | 0.84 | PDK1 (0.53) | PDK1PDK2PDK3PDK4WDR5 | |
| SCHEMBL20288525 | 0.82 | PDK1 (0.69) | PDK1PDK2PDK3PDK4ALDH1A1 | |
| SCHEMBL17809621 | 0.79 | ALDH1A1 (0.50) | PDK1PDK2PDK3PDK4WDR5 | |
| SCHEMBL17809574 | 0.78 | ALDH1A1 (0.51) | WDR5MEN1ALDH1A1GAAMAPT | |
| SCHEMBL2365617 | 0.76 | PDK1 (0.45) | PDK1PDK2PDK3PDK4USP30 | |
| SCHEMBL17795410 | 0.75 | CREBBP (0.54) | WDR5MEN1ALDH1A1GAAMAPT | |
| SCHEMBL17809611 | 0.74 | MEN1 (0.50) | WDR5MEN1ALDH1A1GAAMAPT | |
| SCHEMBL17809770 | 0.73 | WDR5 (0.51) | WDR5MEN1ALDH1A1GAAMAPT | |
| SCHEMBL17809579 | 0.73 | CYP11B1 (0.62) | CYP11B2CYP1A2CYP19A1 | |
| SCHEMBL17809776 | 0.72 | WDR5 (0.53) | WDR5MEN1ALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170333406-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-23 | — | — | US | disclosed |
| US-9763922-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170333406-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC10 | PDK1 395/4885PDK2 1593/4885PDK3 1799/4885 |
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC10 | PDK1 395/4885PDK2 1593/4885PDK3 1799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.