Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 6/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | DHPS | P49366 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779700 | 0.87 | AURKA (0.50) | AURKAABL1BCRPPARGRXFP1 | |
| SCHEMBL3868202 | 0.87 | NPSR1 (0.41) | FGFR4NPSR1ATMLMNA | |
| SCHEMBL1778344 | 0.87 | AURKA (0.43) | AURKAABL1BCRPPARGRXFP1 | |
| SCHEMBL1779328 | 0.86 | RXFP1 (0.44) | AURKAABL1BCRPPARGRXFP1 | |
| SCHEMBL1780795 | 0.86 | AURKA (0.45) | AURKAABL1BCRPPARGRXFP1 | |
| SCHEMBL1778129 | 0.85 | AURKA (0.43) | AURKAABL1BCRPPARGRXFP1 | |
| SCHEMBL1778864 | 0.85 | AURKA (0.41) | AURKAABL1BCRPPARGRXFP1 | |
| SCHEMBL1781218 | 0.85 | AURKA (0.43) | AURKAABL1BCRPPARGRXFP1 | |
| SCHEMBL1780794 | 0.84 | AURKA (0.46) | AURKAABL1BCRPPARGRXFP1 | |
| SCHEMBL1777256 | 0.84 | RXFP1 (0.47) | AURKAABL1BCRRXFP1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |