Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 5/20 | 0.36 |
| ▸ | GLB1 | P16278 | 1/20 | 0.34 |
| ▸ | GUSB | P08236 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16216895 | 1.00 | GBA1 (0.36) | GBA1GLB1GUSB | |
| SCHEMBL18806144 | 0.88 | GBA1 (0.32) | GBA1 | |
| SCHEMBL20109895 | 0.77 | GBA1 (0.39) | GBA1GLB1GUSB | |
| SCHEMBL19885250 | 0.77 | GBA1 (0.37) | GBA1GLB1GUSB | |
| SCHEMBL5044221 | 0.72 | GBA1 (0.39) | GBA1GLB1GUSB | |
| SCHEMBL20115395 | 0.72 | GBA1 (0.42) | GBA1 | |
| SCHEMBL22098589 | 0.72 | GBA1 (0.42) | GBA1 | |
| SCHEMBL13260648 | 0.72 | ATM (0.35) | — | |
| SCHEMBL17282012 | 0.71 | GBA1 (0.37) | GBA1GLB1GUSB | |
| SCHEMBL14827671 | 0.69 | ALDH1A1 (0.37) | GBA1GLB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10028954-B2 | Biheteroaryl compounds and uses thereof | GENENTECH, INC. (US) | 2018-07-24 | — | — | US | disclosed |
| US-20170239246-A9 | BIHETEROARYL COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-08-24 | — | — | US | disclosed |
| US-20160158234-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170239246-A9 | BIHETEROARYL COMPOUNDS AND USES THEREOF | BCHE, SNCA, XDH | GBA1 14/4885GLB1 802/4885GUSB 1700/4885 |
| US-20160158234-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | BCHE, SNCA, XDH | GBA1 14/4885GLB1 802/4885GUSB 1700/4885 |
| US-10028954-B2 | Biheteroaryl compounds and uses thereof | BCHE, SNCA, XDH | GBA1 14/4885GLB1 802/4885GUSB 1700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.