Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9977183 | 0.96 | KDM4E (0.34) | HPGDSSCN10AKDM4EALDH1A1HPGD | |
| SCHEMBL903826 | 0.73 | CHRNB2 (0.41) | SCN10A | |
| SCHEMBL15098648 | 0.73 | CHRNB2 (0.41) | SCN10A | |
| Hydrochloric Acid SCHEMBL240507 | 0.72 | CHRNB2 (0.40) | SCN10A | |
| SCHEMBL7602015 | 0.71 | KDM4E (0.34) | HPGDSSCN10AKDM4EALDH1A1HPGD | |
| SCHEMBL19862537 | 0.71 | NPC1 (0.40) | HPGDSKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL25191098 | 0.71 | HPGDS (0.31) | HPGDS | |
| SCHEMBL9977195 | 0.70 | MAPK13 (0.52) | HPGDSSCN10ANPC1RAB9A | |
| SCHEMBL15883054 | 0.70 | ALDH1A1 (0.42) | ALDH1A1 | |
| SCHEMBL6633132 | 0.69 | KDM4E (0.37) | HPGDSKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3227295-B1 | 6,7-DIHYDROPYRAZOLO[1,5- ]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLU2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-02-20 | — | — | EP | disclosed |
| WO-2016087487-A1 | 6,7-DIHYDROPYRAZOLO[1,5-α]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-09 | — | — | WO | disclosed |