Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL162410 | 0.80 | ERCC5 (0.35) | LOXL2FEN1KDM4EERCC5 | |
| SCHEMBL160966 | 0.79 | ERCC5 (0.31) | FEN1KDM4EERCC5 | |
| SCHEMBL178101 | 0.77 | DGAT1 (0.42) | GRIA4TP53FEN1ERCC5 | |
| SCHEMBL178104 | 0.77 | DGAT1 (0.42) | GRIA4TP53FEN1ERCC5 | |
| SCHEMBL176236 | 0.72 | DGAT1 (0.54) | KDM4E | |
| SCHEMBL174942 | 0.71 | DGAT1 (0.48) | FEN1ERCC5 | |
| SCHEMBL161582 | 0.70 | CTSK (0.30) | — | |
| SCHEMBL171266 | 0.68 | XDH (0.44) | KDM4E | |
| SCHEMBL15022160 | 0.66 | DGAT1 (0.41) | GRIA4LOXL2TP53FEN1ALOX5AP | |
| SCHEMBL15022157 | 0.66 | DGAT1 (0.41) | GRIA4LOXL2TP53FEN1ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |