Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
| ▸ | PTP4A3 | O75365 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.35 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717835 | 0.85 | TDP2 (0.42) | CDC7ROCK1DBF4PTP4A3PDE3B | |
| SCHEMBL14719196 | 0.85 | PTP4A3 (0.48) | CDC7ROCK1DBF4PTP4A3PDE3B | |
| SCHEMBL14717979 | 0.76 | MEN1 (0.46) | PDE3BPDE3AEPHX2GRIA1CACNG8 | |
| SCHEMBL5209408 | 0.67 | CDC7 (0.41) | CDC7DBF4MAPTALDH1A1HPGD | |
| SCHEMBL26998804 | 0.66 | PDE3B (0.50) | PDE3BPDE3AEPHX2GRIA1CACNG8 | |
| SCHEMBL22013197 | 0.65 | PTP4A3 (0.74) | CDC7ROCK1DBF4PTP4A3MEN1 | |
| SCHEMBL11521591 | 0.63 | ESR1 (0.66) | PTP4A3MAPTSMN1; SMN2LMNANPSR1 | |
| SCHEMBL14718279 | 0.62 | PDE3B (0.38) | PDE3BPDE3AMAPTALDH1A1HPGD | |
| SCHEMBL16546086 | 0.62 | PTP4A3 (0.42) | PTP4A3MAPTHPGDRAB9ASMN1; SMN2 | |
| SCHEMBL10711573 | 0.62 | GRIA1 (0.42) | PDE3BPDE3AMAPTEPHX2GRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365584-B2 | Thieno [2,3-B] pyridinedione activators of AMPK and therapeutic uses thereof | POXEL (FR) | 2016-06-14 | — | — | US | disclosed |