Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTP4A3 | O75365 | 3/20 | 0.48 |
| ▸ | PTP4A2 | Q12974 | 2/20 | 0.46 |
| ▸ | PTP4A1 | Q93096 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TDP2 | O95551 | 4/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717835 | 0.85 | TDP2 (0.42) | PTP4A3RAB9AALDH1A1HPGDTDP2 | |
| SCHEMBL17811463 | 0.85 | CDC7 (0.38) | PTP4A3PTP4A2PTP4A1RAB9AALDH1A1 | |
| SCHEMBL14717979 | 0.71 | MEN1 (0.46) | RAB9AALDH1A1LMNAHPGDGAA | |
| SCHEMBL13312445 | 0.70 | BRD4 (0.44) | ALDH1A1TDP2CHEK1AURKADAPK3 | |
| SCHEMBL26299788 | 0.70 | PTP4A3 (0.49) | PTP4A3PTP4A2PTP4A1RAB9AALDH1A1 | |
| SCHEMBL13312392 | 0.68 | MAOA (0.58) | RAB9AALDH1A1SMN1; SMN2NPC1LMNA | |
| SCHEMBL17811546 | 0.68 | PGR (0.40) | RAB9AALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL17811547 | 0.67 | SMN1; SMN2 (0.37) | RAB9AALDH1A1SMN1; SMN2NPC1HPGD | |
| SCHEMBL26299786 | 0.67 | PTP4A3 (0.49) | PTP4A3PTP4A2PTP4A1RAB9AALDH1A1 | |
| SCHEMBL1823319 | 0.66 | PTP4A3 (0.45) | PTP4A3PTP4A2PTP4A1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365584-B2 | Thieno [2,3-B] pyridinedione activators of AMPK and therapeutic uses thereof | POXEL (FR) | 2016-06-14 | — | — | US | disclosed |
| US-20130053401-A1 | THIENO [2,3-B] PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | POXEL (FR) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053401-A1 | THIENO [2,3-B] PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | PRKAB1, PRKAG1, PRKAB2 | PTP4A3 1792/4885PTP4A2 1774/4885PTP4A1 1965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.