Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 5/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PRF1 | P14222 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | WRN | Q14191 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17811463 | 0.85 | CDC7 (0.38) | CDC7ROCK1DBF4RAB9AMEN1 | |
| SCHEMBL14719196 | 0.85 | PTP4A3 (0.48) | TDP2CDC7ROCK1DBF4RAB9A | |
| SCHEMBL14717979 | 0.69 | MEN1 (0.46) | CYP2C19RAB9AMEN1KMT2APDE3B | |
| SCHEMBL23326172 | 0.66 | PDE3B (0.58) | TDP2CYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL793215 | 0.65 | CDC7 (0.72) | PDPK1CDC7DBF4 | |
| SCHEMBL22013811 | 0.65 | PTP4A3 (0.74) | TDP2PDPK1IKBKBCHUKCYP1A2 | |
| SCHEMBL14718279 | 0.62 | PDE3B (0.38) | TDP2MEN1EIF2AK2KMT2APDE3B | |
| SCHEMBL6319355 | 0.62 | GSK3B (0.49) | CYP3A4CYP2C9CYP2C19JAK2MAPT | |
| SCHEMBL5843103 | 0.62 | CRBN (0.57) | TDP2EIF2AK2PDE3BPDE3A | |
| SCHEMBL1897593 | 0.62 | PDE3B (0.68) | TDP2CYP1A2PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130053401-A1 | THIENO [2,3-B] PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | POXEL (FR) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053401-A1 | THIENO [2,3-B] PYRIDINEDIONE ACTIVATORS OF AMPK AND THERAPEUTIC USES THEREOF | PRKAB1, PRKAG1, PRKAB2 | TDP2 3431/4885PDPK1 84/4885IKBKB 717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.