Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 2/20 | 0.33 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17811628 | 0.91 | RIPK1 (0.32) | — | |
| SCHEMBL24252084 | 0.80 | KCNH2 (0.33) | KCNH2HRH3CNR2 | |
| SCHEMBL16455087 | 0.80 | NOS3 (0.35) | NOS3NOS1NOS2 | |
| SCHEMBL22309037 | 0.78 | HRH4 (0.32) | — | |
| SCHEMBL16455139 | 0.77 | NOS3 (0.33) | NOS3NOS1NOS2 | |
| SCHEMBL17811634 | 0.72 | GRM5 (0.33) | — | |
| SCHEMBL16455143 | 0.69 | RIPK1 (0.34) | NOS3NOS1NOS2 | |
| SCHEMBL20221922 | 0.69 | APP (0.38) | — | |
| SCHEMBL18889351 | 0.68 | NOS3 (0.40) | NOS3NOS1NOS2HRH3 | |
| SCHEMBL22833834 | 0.68 | NOS3 (0.36) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9605004-B2 | Chemical compounds | SYNGENTA LIMITED (GB) | 2017-03-28 | — | — | US | disclosed |
| US-9605004-B2 | Chemical compounds | SYNGENTA LIMITED (GB) | 2017-03-28 | — | — | US | disclosed |
| US-20160168126-A1 | CHEMICAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2016-06-16 | — | — | US | disclosed |
| US-20160159819-A1 | CHEMICAL COMPOUNDS | SYNGENTA LIMITED (GB) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168126-A1 | CHEMICAL COMPOUNDS | RDX, CBR3, RRS1 | NOS3 907/4885NOS1 1126/4885NOS2 1670/4885 |
| US-20160159819-A1 | CHEMICAL COMPOUNDS | RDX, CBR3, RRS1 | NOS3 853/4885NOS1 948/4885NOS2 1434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.