Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.47 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL178251 | 0.91 | NTRK1 (0.45) | DGAT1P2RY1EPHX2NTRK1CA12 | |
| SCHEMBL175407 | 0.89 | DGAT1 (0.47) | DGAT1KDRHDAC6 | |
| SCHEMBL176339 | 0.83 | DGAT1 (0.52) | DGAT1CA12CA1CA2MAPT | |
| SCHEMBL15021989 | 0.81 | EPHX2 (0.47) | DGAT1P2RY1EPHX2CA12CA1 | |
| SCHEMBL174941 | 0.80 | DGAT1 (0.46) | DGAT1KDRMEN1KMT2A | |
| SCHEMBL178117 | 0.79 | EPHX2 (0.45) | DGAT1P2RY1EPHX2NTRK1CA12 | |
| SCHEMBL164989 | 0.78 | DGAT1 (0.48) | DGAT1P2RY1EPHX2KDRMEN1 | |
| SCHEMBL15022122 | 0.78 | EPHX2 (0.44) | DGAT1P2RY1EPHX2NTRK1CA12 | |
| SCHEMBL178250 | 0.77 | EPHX2 (0.43) | DGAT1P2RY1EPHX2NTRK1CA12 | |
| SCHEMBL162274 | 0.77 | DGAT1 (0.45) | DGAT1P2RY1EPHX2NTRK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |