Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.54 |
| ▸ | NOS2 | P35228 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 7/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4915813 | 0.87 | NOS3 (0.60) | NOS3NOS2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3711167 | 0.83 | MEN1 (0.47) | NOS3NOS2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16840718 | 0.83 | NOS3 (0.45) | NOS3NOS2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29849205 | 0.83 | MEN1 (0.47) | NOS3NOS2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16841139 | 0.79 | GAA (0.46) | NOS3NOS2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16840732 | 0.79 | NOS3 (0.42) | NOS3NOS2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL25846980 | 0.79 | NOS3 (0.42) | NOS3NOS2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16543304 | 0.78 | TLR8 (0.54) | NOS3NOS2SMN1; SMN2ALDH1A1 | |
| SCHEMBL16840720 | 0.78 | KDM4E (0.50) | NOS3NOS2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16840721 | 0.78 | NPC1 (0.50) | NOS3NOS2RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160158230-A1 | 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER | SERVIER PHARMACEUTICALS LLC | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160158230-A1 | 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER | IDH2, IDH3B, IDH3A | NOS3 3211/4885NOS2 2331/4885RAB9A 3473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.