Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31453693 | 0.82 | ALDH1A1 (0.45) | KDM4EHSP90AA1HSP90AB1HPGDATM | |
| SCHEMBL25846980 | 0.82 | NOS3 (0.42) | KDM4ENOS3NOS2ALDH1A1KMT2A | |
| SCHEMBL10271825 | 0.80 | HSP90AA1 (0.52) | KDM4EHSP90AA1HSP90AB1HPGDATM | |
| SCHEMBL22247617 | 0.78 | KDM4E (0.49) | KDM4EHSP90AA1HSP90AB1NOS3NOS2 | |
| SCHEMBL17812892 | 0.78 | NOS3 (0.54) | NOS3NOS2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL25065895 | 0.76 | KDM4E (0.46) | KDM4EHSP90AA1HSP90AB1NOS3NOS2 | |
| SCHEMBL14927263 | 0.74 | HSP90AA1 (0.63) | KDM4EHSP90AA1HSP90AB1HPGDATM | |
| Hydrochloric Acid SCHEMBL28210241 | 0.73 | KDM4E (0.44) | KDM4EHSP90AA1HSP90AB1HPGDATM | |
| SCHEMBL27776507 | 0.73 | SDHB (0.54) | KDM4EHPGDALDH1A1KMT2AMAPT | |
| Ammonia Solution, Strong SCHEMBL15795498 | 0.72 | HSP90AA1 (0.61) | KDM4EHSP90AA1HSP90AB1HPGDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015091584-A1 | THIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS TYK2 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-06-25 | — | — | WO | disclosed |