Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.45 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16392139 | 0.85 | IDH1 (0.53) | ABCG2ABCB1ABCC1CYP1A2IDH1 | |
| SCHEMBL16391808 | 0.84 | TGFBR1 (0.46) | ABCG2ABCB1ABCC1TGFBR1CYP1A2 | |
| SCHEMBL17812903 | 0.83 | TGFBR1 (0.46) | TGFBR1MAP3K12CYP1A2CLK4MAP4K4 | |
| SCHEMBL17812899 | 0.83 | CYP1A2 (0.52) | ABCG2ABCB1ABCC1TGFBR1CYP1A2 | |
| SCHEMBL17812909 | 0.81 | IDH2 (0.50) | TGFBR1MAP3K12CYP1A2CLK4MAP4K4 | |
| SCHEMBL17812917 | 0.80 | TGFBR1 (0.57) | ABCG2ABCB1ABCC1TGFBR1CYP1A2 | |
| SCHEMBL17812902 | 0.77 | TGFBR1 (0.59) | ABCG2ABCB1ABCC1TGFBR1CYP1A2 | |
| SCHEMBL16392068 | 0.76 | ABCG2 (0.58) | ABCG2ABCB1ABCC1CYP1A2GRM5 | |
| SCHEMBL17812901 | 0.76 | TGFBR1 (0.46) | ABCG2ABCB1ABCC1TGFBR1CYP1A2 | |
| SCHEMBL17812910 | 0.75 | CYP1A2 (0.55) | TGFBR1CYP1A2IDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160158230-A1 | 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER | SERVIER PHARMACEUTICALS LLC | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160158230-A1 | 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER | IDH2, IDH3B, IDH3A | ABCG2 889/4885ABCB1 828/4885ABCC1 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.