Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | IDH1 | O75874 | 8/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16391813 | 0.89 | IDH1 (0.53) | IDH2CYP1A2IDH1 | |
| SCHEMBL17812903 | 0.84 | TGFBR1 (0.46) | IDH2CYP1A2TGFBR1SYKIDH1 | |
| SCHEMBL16391808 | 0.83 | TGFBR1 (0.46) | IDH2CYP1A2TGFBR1IDH1FFAR1 | |
| SCHEMBL16391622 | 0.82 | IDH2 (0.56) | IDH2CYP1A2SYKIDH1 | |
| SCHEMBL17812905 | 0.82 | SYK (0.50) | IDH2TGFBR1SYKIDH1MAP3K12 | |
| SCHEMBL17812899 | 0.81 | CYP1A2 (0.52) | IDH2CYP1A2TGFBR1IDH1FFAR1 | |
| SCHEMBL17812908 | 0.81 | ABCG2 (0.48) | IDH2CYP1A2TGFBR1IDH1MAP3K12 | |
| SCHEMBL17812910 | 0.80 | CYP1A2 (0.55) | IDH2CYP1A2TGFBR1IDH1 | |
| SCHEMBL17812917 | 0.78 | TGFBR1 (0.57) | IDH2CYP1A2TGFBR1IDH1FFAR1 | |
| SCHEMBL17812906 | 0.78 | SYK (0.50) | IDH2TGFBR1SYKMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160158230-A1 | 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER | SERVIER PHARMACEUTICALS LLC | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160158230-A1 | 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER | IDH2, IDH3B, IDH3A | IDH2 1/4885CYP1A2 197/4885TGFBR1 3893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.