Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 5/20 | 0.47 |
| ▸ | IDH1 | O75874 | 4/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16391607 | 0.93 | IDH1 (0.54) | IDH2IDH1ABCB11ADORA3CHRM1 | |
| SCHEMBL17812912 | 0.87 | PTGS2 (0.49) | PTGS2CLK4DYRK1AMAPTTP53 | |
| SCHEMBL16391740 | 0.79 | PTGS2 (0.51) | IDH2IDH1ABCB11ADORA3CHRM1 | |
| SCHEMBL17812918 | 0.79 | TGFBR1 (0.54) | IDH2IDH1ABCB11ADORA3CHRM1 | |
| SCHEMBL16392119 | 0.76 | IDH1 (0.56) | IDH2IDH1ABCB11ADORA3CHRM1 | |
| SCHEMBL16391967 | 0.75 | IDH1 (0.58) | IDH2IDH1ABCB11ADORA3CHRM1 | |
| SCHEMBL16391840 | 0.75 | IDH1 (0.75) | IDH2IDH1ABCB11ADORA3CHRM1 | |
| SCHEMBL16391748 | 0.73 | IDH2 (0.70) | IDH2IDH1ABCB11ADORA3CHRM1 | |
| SCHEMBL21977206 | 0.73 | IDH1 (0.60) | IDH2IDH1ABCB11ADORA3CHRM1 | |
| SCHEMBL16392109 | 0.73 | IDH1 (0.64) | IDH2IDH1ABCB11ADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160158230-A1 | 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER | SERVIER PHARMACEUTICALS LLC | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160158230-A1 | 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER | IDH2, IDH3B, IDH3A | IDH2 1/4885IDH1 4/4885ABCB11 2849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.