Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | DPP4 | P27487 | 7/20 | 0.49 |
| ▸ | FAP | Q12884 | 5/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | PREP | P48147 | 2/20 | 0.40 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19334937 | 1.00 | KDM4E (0.53) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL12709880 | 0.85 | KDM4E (0.58) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL13371727 | 0.84 | DPP4 (0.47) | CYP2D6MAPK1DPP4FAPDPP8 | |
| SCHEMBL13347197 | 0.84 | DPP4 (0.47) | CYP2D6MAPK1DPP4FAPDPP8 | |
| Hydrochloric Acid SCHEMBL6187783 | 0.81 | KDM4E (0.51) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL17814288 | 0.78 | DPP4 (0.57) | DPP4FAPDPP8DPP9DPP7 | |
| SCHEMBL9038091 | 0.77 | KDM4E (0.46) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| Cyclomethyltryptophan SCHEMBL416558 | 0.74 | KDM4E (0.71) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| Cyclomethyltryptophan SCHEMBL7889282 | 0.74 | KDM4E (0.71) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 | |
| Cyclomethyltryptophan SCHEMBL416557 | 0.74 | KDM4E (0.71) | KDM4ECYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170333461-A1 | PEPTIDOMIMETIC INHIBITORS OF POST-PROLINE CLEAVING ENZYMES | BACH BIOSCIENCES, LLC | 2017-11-23 | — | — | US | disclosed |
| US-9757400-B2 | Peptidomimetic inhibitors of post-proline cleaving enzymes | TRUSTEES OF TUFTS COLLEGE (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160158260-A1 | Peptidomimetic Inhibitors of Post-Proline Cleaving Enzymes | BACH BIOSCIENCES, LLC | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170333461-A1 | PEPTIDOMIMETIC INHIBITORS OF POST-PROLINE CLEAVING ENZYMES | PREP, PEPD, DNPEP | KDM4E 3079/4885CYP1A2 2361/4885CYP2D6 1755/4885 |
| US-20160158260-A1 | Peptidomimetic Inhibitors of Post-Proline Cleaving Enzymes | PREP, PEPD, DNPEP | KDM4E 3079/4885CYP1A2 2361/4885CYP2D6 1755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.