⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17815526 | 1.00 | — | — | |
| SCHEMBL5069027 | 1.00 | — | — | |
| SCHEMBL4937186 | 0.88 | NOS1 (0.41) | — | |
| SCHEMBL571633 | 0.86 | NOS3 (0.37) | — | |
| SCHEMBL11494956 | 0.81 | NOS3 (0.34) | — | |
| SCHEMBL9354085 | 0.79 | NOS3 (0.33) | — | |
| SCHEMBL9354075 | 0.79 | NOS3 (0.33) | — | |
| SCHEMBL17815519 | 0.79 | FAAH (0.34) | — | |
| SCHEMBL17815521 | 0.79 | FAAH (0.34) | — | |
| SCHEMBL11667173 | 0.79 | NOS3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3228616-B1 | PYRIDINE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2019-10-16 | — | — | EP | disclosed |
| US-10005762-B2 | Pyridine derivatives | ASTELLAS PHARMA INC. (JP) | 2018-06-26 | — | — | US | disclosed |
| US-10005762-B2 | Pyridine derivatives | ASTELLAS PHARMA INC. (JP) | 2018-06-26 | — | — | US | disclosed |
| US-20170362209-A1 | PYRIDINE DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2017-12-21 | — | — | US | disclosed |
| US-20170362209-A1 | PYRIDINE DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2017-12-21 | — | — | US | disclosed |
| EP-3228616-A1 | PYRIDINE DERIVATIVES | Astellas Pharma Inc. (JP) | 2017-10-11 | — | — | EP | disclosed |
| WO-2016088864-A1 | PYRIDINE DERIVATIVE | アステラス製薬株式会社 | 2016-06-09 | — | — | WO | disclosed |