Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.34 |
| ▸ | RAB9A | P51151 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17815699 | 0.84 | MCHR1 (0.43) | CHRNB4CHRNA3PDE4B | |
| SCHEMBL17815743 | 0.81 | IDH1 (0.36) | CHRNB4CHRNA3APOBEC3AAPOBEC3GNPC1 | |
| SCHEMBL17815736 | 0.79 | SCN9A (0.33) | CHRNB4CHRNA3APOBEC3AAPOBEC3GNPC1 | |
| SCHEMBL11396539 | 0.78 | ALDH1A1 (0.53) | CHRNB4CHRNA3APOBEC3AAPOBEC3GNPC1 | |
| SCHEMBL17815701 | 0.78 | PDE4B (0.38) | APOBEC3AAPOBEC3GNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17815782 | 0.76 | IDH1 (0.34) | CHRNB4CHRNA3APOBEC3AAPOBEC3GNPC1 | |
| SCHEMBL17815786 | 0.76 | LRRK2 (0.39) | CHRNB4CHRNA3FFAR4 | |
| SCHEMBL20116553 | 0.76 | KDM4E (0.51) | APOBEC3AAPOBEC3GNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27849575 | 0.73 | NPC1 (0.41) | APOBEC3AAPOBEC3GNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10304986 | 0.73 | RAB9A (0.45) | APOBEC3AAPOBEC3GNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160159815-A1 | Fused Piperidine Amides as Modulators of Ion Channels | VERTEX PHARMACEUTICALS INCORPORATED | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159815-A1 | Fused Piperidine Amides as Modulators of Ion Channels | TRPV1, TRPA1, KCNJ2 | CHRNB4 321/4885CHRNA3 211/4885APOBEC3A 4225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.