Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.59 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13978073 | 1.00 | AGXT (0.63) | AGXTTDP1KDM4EMAPK1ALOX5 | |
| SCHEMBL12354082 | 0.83 | TDP1 (0.68) | AGXTTDP1KDM4EMAPK1ALOX5 | |
| SCHEMBL16902860 | 0.81 | AGXT (0.68) | AGXTTDP1KDM4EMAPK1ALOX5 | |
| SCHEMBL16902851 | 0.81 | TDP1 (0.87) | AGXTTDP1KDM4EMAPK1ALOX5 | |
| SCHEMBL12668171 | 0.81 | TDP1 (0.66) | AGXTTDP1KDM4EMAPK1ALOX5 | |
| SCHEMBL29550888 | 0.81 | TDP1 (0.66) | AGXTTDP1KDM4EMAPK1ALOX5 | |
| SCHEMBL470910 | 0.81 | TDP1 (0.66) | AGXTTDP1KDM4EMAPK1ALOX5 | |
| SCHEMBL13978299 | 0.81 | TDP1 (0.65) | AGXTTDP1KDM4EMAPK1ALOX5 | |
| SCHEMBL29431777 | 0.79 | CYP1A2 (0.48) | AGXTTDP1ALOX5PTPN7CYP1A2 | |
| SCHEMBL10280744 | 0.79 | CYP2A6 (0.54) | AGXTTDP1KDM4EMAPK1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180037526-A1 | TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2018-02-08 | — | — | US | disclosed |
| US-20160158388-A1 | TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160158388-A1 | TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION | AFF2, CLTC, AFF4 | AGXT 2970/4885TDP1 3753/4885KDM4E 1877/4885 |
| US-20180037526-A1 | TARGETED, METAL-CATALYZED FLUORINATION OF COMPLEX COMPOUNDS WITH FLUORIDE ION VIA DECARBOXYLATION | AFF2, CLTC, AFF4 | AGXT 2970/4885TDP1 3753/4885KDM4E 1877/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.