SCHEMBL17816341

SCHEMBL17816341

NC1=N[C@@H](Cc2c(F)cccc2F)CO1

nearest known ligand 0.66

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3619335 0.90 TAAR1 (0.62) TAAR1
SCHEMBL3619338 0.90 TAAR1 (0.62) TAAR1
SCHEMBL3622246 0.89 TAAR1 (0.51) TAAR1
SCHEMBL3622251 0.89 TAAR1 (0.51) TAAR1
SCHEMBL3621037 0.83 TAAR1 (0.68) TAAR1
SCHEMBL3621041 0.83 TAAR1 (0.68) TAAR1
SCHEMBL3620936 0.81 TAAR1 (0.49) TAAR1
SCHEMBL3620940 0.81 TAAR1 (0.49) TAAR1
SCHEMBL3621916 0.81 TAAR1 (0.59) TAAR1
SCHEMBL20462498 0.81 TAAR1 (0.41) TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10632105-B2 Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL) (CH) 2020-04-28 US disclosed
US-20190022371-A1 ELECTRODE ARRAY FOR TRANSCUTANEOUS ELECTRICAL STIMULATION OF THE SPINAL CORD AND USES THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2019-01-24 US disclosed
US-20180221651-A1 METHODS OF FABRICATING AN ELECTRODE ARRAY FOR TRANSCUTANEOUS ELECTRICAL STIMULATION OF THE SPINAL CORD UNIV CALIFORNIA (US) 2018-08-09 US disclosed
US-20160158204-A1 PHARMACOLOGICAL STIMULATION TO FACILITATE AND RESTORE STANDING AND WALKING FUNCTIONS IN SPINAL CORD MOTOR DISORDERS ONWARD MEDICAL N.V. (NL) 2016-06-09 US disclosed
US-20160158204-A1 PHARMACOLOGICAL STIMULATION TO FACILITATE AND RESTORE STANDING AND WALKING FUNCTIONS IN SPINAL CORD MOTOR DISORDERS ONWARD MEDICAL N.V. (NL) 2016-06-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10632105-B2 Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders ADRA2C, ADRA2A, ADRB2 TAAR1 235/4885
US-20160158204-A1 PHARMACOLOGICAL STIMULATION TO FACILITATE AND RESTORE STANDING AND WALKING FUNCTIONS IN SPINAL CORD MOTOR DISORDERS ADRA2C, ADRA2A, ADRB2 TAAR1 235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.